Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.61 |
| ▸ | PIM1 | P11309 | 3/20 | 0.61 |
| ▸ | PRKACA | P17612 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.61 |
| ▸ | PRKCG | P05129 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608525 | 0.89 | ROCK1 (0.79) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL3596684 | 0.84 | AURKB (0.56) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL3608714 | 0.81 | ROCK1 (0.46) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL3605135 | 0.76 | DYRK1A (1.00) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL1852515 | 0.75 | CHEK1 (0.84) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL3596197 | 0.74 | PRKG1 (0.79) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL14493878 | 0.73 | CCNT1 (0.50) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL3595645 | 0.73 | CHEK1 (0.71) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL30009302 | 0.71 | JAK1 (0.52) | AKT3ROCK1ROCK2CHEK1MAP4K4 | |
| SCHEMBL30009520 | 0.71 | JAK1 (0.62) | AKT3ROCK1ROCK2CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ROCK1, ROCK2, RHOA | AKT3 24/4885ROCK1 1/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.