Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PNMT | P11086 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653187 | 0.86 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| SCHEMBL11030540 | 0.86 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1PNMTADRA2AMAPT | |
| SCHEMBL5445373 | 0.84 | TSHR (0.56) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| SCHEMBL7514000 | 0.81 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| SCHEMBL27510090 | 0.81 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| Hydrochloric Acid SCHEMBL7513995 | 0.80 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| SCHEMBL4491436 | 0.80 | MAPKAPK2 (0.46) | MAPTKDM1AMAPKAPK2PKM | |
| SCHEMBL8210443 | 0.78 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| SCHEMBL1013537 | 0.78 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R | |
| Hydrochloric Acid SCHEMBL7510081 | 0.77 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1PNMTADRA2ATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | ALDH1A1 88/4885L3MBTL1 3083/4885PNMT 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.