Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 5/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223727 | 0.74 | FFAR4 (0.43) | — | |
| SCHEMBL28543770 | 0.72 | GLA (0.39) | MIFHDAC6GLA | |
| SCHEMBL28543772 | 0.72 | GLA (0.39) | MIFHDAC6GLA | |
| SCHEMBL360600 | 0.72 | — | — | |
| SCHEMBL2210266 | 0.72 | BRD4 (0.44) | BRD4SMN1; SMN2 | |
| SCHEMBL908733 | 0.68 | PRKCA (0.42) | PRKCAMIFHDAC6BRD4SMN1; SMN2 | |
| SCHEMBL2906560 | 0.68 | BRD4 (0.35) | BRD4SMN1; SMN2 | |
| SCHEMBL23035036 | 0.67 | TP53 (0.34) | GLA | |
| SCHEMBL368760 | 0.67 | — | — | |
| SCHEMBL22750444 | 0.66 | BRD4 (0.45) | BRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009217-A1 | SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |