⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044057 | 0.80 | — | — | |
| SCHEMBL4106091 | 0.80 | — | — | |
| SCHEMBL13101034 | 0.78 | MAPT (0.33) | — | |
| SCHEMBL12126287 | 0.76 | — | — | |
| SCHEMBL306662 | 0.74 | HSP90AA1 (0.39) | — | |
| Acetamide SCHEMBL1483478 | 0.72 | KEAP1 (0.42) | — | |
| SCHEMBL17489137 | 0.72 | ALOX15 (0.50) | — | |
| SCHEMBL13924793 | 0.71 | KDM4C (0.40) | — | |
| SCHEMBL22057261 | 0.71 | ALOX15 (0.36) | — | |
| SCHEMBL18397623 | 0.71 | ALOX15 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355221-A1 | Targeting the Non-Canonical NFkB Pathway in Cancer Immunotherapy | THE GENERAL HOSPITAL CORPORATION | 2021-11-18 | — | — | US | claimed |
| WO-2020082016-A1 | TARGETING THE NON-CANONICAL NFKB PATHWAY IN CANCER IMMUNOTHERAPY | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-23 | — | — | WO | claimed |
| EP-4399202-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2024-07-17 | — | — | EP | disclosed |
| WO-2023072962-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4169904-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2023-04-26 | — | — | EP | disclosed |
| CN-112062754-B | Preparation method of intermediate for synthesizing Dorzagliatin | 深圳市华先医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |
| US-20210355221-A1 | Targeting the Non-Canonical NFkB Pathway in Cancer Immunotherapy | THE GENERAL HOSPITAL CORPORATION | 2021-11-18 | — | — | US | disclosed |
| CN-112062754-A | Preparation method of intermediate for synthesizing Dorzagliatin | 深圳市华先医药科技有限公司 | 2020-12-11 | — | — | CN | disclosed |
| WO-2020082016-A1 | TARGETING THE NON-CANONICAL NFKB PATHWAY IN CANCER IMMUNOTHERAPY | THE GENERAL HOSPITAL CORPORATION (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-1600442-B1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | MSD KK (JP) | 2018-01-17 | — | — | EP | disclosed |
| US-8530646-B2 | Oxazolidinone derivative having 7-membered hetero ring | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2013-09-10 | — | — | US | disclosed |
| EP-2208729-A1 | OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING | Research Foundation Itsuu Laboratory (JP) | 2010-07-21 | — | — | EP | disclosed |
| US-7754743-B2 | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |
| CN-101712657-A | heteroarylcarbamoylbenzene derivative | BANYU PHARMA CO LTD | 2010-05-26 | — | — | CN | disclosed |
| CN-100591671-C | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMA CO LTD | 2010-02-24 | — | — | CN | disclosed |
| US-20090018056-A1 | Heteroarylcarbamoylbenzene derivatives | MSD K.K. (JP) | 2009-01-15 | — | — | US | disclosed |
| US-7432287-B2 | Heteroarylcarbamoylbenzene derivative | BANYU PHARMECEUTICAL CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-20060167053-A1 | Heteroarylcarbamoylbenzene derivative | MSD K.K. (JP) | 2006-07-27 | — | — | US | disclosed |
| CN-1777589-A | Heteroarylcarbamoylbenzene derivatives | BANYU PHARMA CO LTD (JP) | 2006-05-24 | — | — | CN | disclosed |
| EP-1600442-A1 | HETEROARYLCARBAMOYLBENZENE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-30 | — | — | EP | disclosed |