SCHEMBL3604433

SCHEMBL3604433

Cc1cc(N)cc(C)c1NC(=O)CC(C)(C)C

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.60
KCNQ2 O43526 16/20 0.56
LMNA P02545 1/20 0.49
MEN1 O00255 1/20 0.47
HPGD P15428 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23177820 0.86 L3MBTL1 (0.79) L3MBTL1KCNQ2LMNAMEN1HPGD
SCHEMBL751185 0.83 L3MBTL1 (0.65) L3MBTL1KCNQ2MEN1HPGDKMT2A
SCHEMBL8369000 0.83 L3MBTL1 (0.60) L3MBTL1KCNQ2LMNAMEN1HPGD
SCHEMBL23142182 0.83 L3MBTL1 (0.60) L3MBTL1KCNQ2LMNAMEN1HPGD
SCHEMBL20421907 0.82 L3MBTL1 (0.56) L3MBTL1KCNQ2LMNAMEN1HPGD
SCHEMBL14263863 0.80 TSHR (0.57) L3MBTL1LMNAMEN1HPGDKMT2A
SCHEMBL31519821 0.80 L3MBTL1 (0.57) L3MBTL1KCNQ2MEN1HPGDKMT2A
SCHEMBL3112925 0.80 L3MBTL1 (0.57) L3MBTL1KCNQ2MEN1HPGDKMT2A
SCHEMBL30795680 0.80 L3MBTL1 (0.57) L3MBTL1KCNQ2MEN1HPGDKMT2A
SCHEMBL23177713 0.79 L3MBTL1 (0.56) L3MBTL1KCNQ2MEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100063044-A1 SUBSTITUTED ANILINE DERIVATIVES H. LUNDBECK A/S (DK) 2010-03-11 US disclosed
US-7601870-B2 Such as Hexanoic acid (4-bromo-2,6-dimethyl-phenyl)-amide; potassium channel modulators; epilepsy H. LUNDBECK A/S (DK) 2009-10-13 US disclosed
CN-101056845-A Substituted aniline derivatives LUNDBECK & CO AS H (DK) 2007-10-17 CN disclosed
EP-1791809-A1 SUBSTITUTED ANILINE DERIVATIVES H. LUNDBECK A/S (DK) 2007-06-06 EP disclosed
US-20060155121-A1 Substituted aniline derivatives H. LUNDBECK A/S (DK) 2006-07-13 US disclosed
WO-2006029623-A1 SUBSTITUTED ANILINE DERIVATIVES H. LUNDBECK A/S (DK) 2006-03-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063044-A1 SUBSTITUTED ANILINE DERIVATIVES NDUFS3, NAT1, PRMT3 L3MBTL1 1647/4885KCNQ2 332/4885LMNA 1314/4885
US-20060155121-A1 Substituted aniline derivatives UGT2B7, NAT1, CYP1A2 L3MBTL1 3592/4885KCNQ2 2118/4885LMNA 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.