Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | DVL1 | O14640 | 1/20 | 0.39 |
| ▸ | DVL3 | Q92997 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3597229 | 1.00 | MAOA (0.49) | MAOAPARP1CDK4CDK2CDK5 | |
| SCHEMBL3615614 | 0.92 | MAOA (0.56) | MAOAPARP1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3613688 | 0.92 | MAOA (0.56) | MAOAPARP1ALDH1A1HSD17B10MAPT | |
| SCHEMBL3613693 | 0.92 | MAOA (0.56) | MAOAPARP1ALDH1A1HSD17B10MAPT | |
| Trifluoroacetic Acid SCHEMBL3613647 | 0.88 | ADORA1 (0.47) | CDK4CDK2CDK5ALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3607518 | 0.88 | ADORA1 (0.47) | CDK4CDK2CDK5ALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3602182 | 0.86 | PTGS2 (0.56) | CDK4CDK2CDK5ALDH1A1MAPT | |
| SCHEMBL3607862 | 0.85 | MAOA (0.51) | MAOAPARP1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL3608639 | 0.85 | MAOA (0.51) | MAOAPARP1CDK2ALDH1A1HSD17B10 | |
| SCHEMBL3607864 | 0.85 | MAOA (0.51) | MAOAPARP1CDK2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
| WO-2009158375-A1 | AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | MAOA 31/4885PARP1 156/4885CDK4 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.