Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | RPS6KA2 | Q15349 | 8/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602522 | 0.91 | SMN1; SMN2 (0.60) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| SCHEMBL3608431 | 0.91 | NAMPT (0.56) | SMN1; SMN2NAMPTCYP1A2MAPTCYP2C9 | |
| SCHEMBL13504884 | 0.90 | NAMPT (0.60) | NAMPTRPS6KA2ALDH1A1RPS6KA3 | |
| SCHEMBL13504909 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| SCHEMBL3608690 | 0.90 | TAS2R8 (0.52) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| Hydrochloric Acid SCHEMBL3612494 | 0.90 | NAMPT (0.59) | NAMPTRPS6KA2ALDH1A1RPS6KA3 | |
| Hydrochloric Acid SCHEMBL3610939 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| SCHEMBL3613929 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| SCHEMBL3605849 | 0.88 | NAMPT (0.49) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B | |
| Hydrochloric Acid SCHEMBL3596683 | 0.88 | SMN1; SMN2 (0.58) | SMN1; SMN2NAMPTRPS6KA2WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | claimed |
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
| US-20100041696-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2010-02-18 | — | — | US | disclosed |
| WO-2008074824-A2 | ISOQUINOLINECARBOXAMIDES AS INHIBITORS OF STEAROYL-COA DESATURASE (SCD) | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041696-A1 | Compounds | CYP11B2, SCD, CYP3A5 | SMN1; SMN2 618/4885NAMPT 869/4885RPS6KA2 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.