SCHEMBL3606936

SCHEMBL3606936

CCOc1cccc(C)c1S(=O)(=O)N=C=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
KDM4E B2RXH2 2/20 0.36
PABPC1 P11940 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GRK6 P43250 1/20 0.36
LMNA P02545 4/20 0.35
L3MBTL1 Q9Y468 3/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.35
RECQL P46063 1/20 0.35
ALDH1A1 P00352 3/20 0.34
NPSR1 Q6W5P4 1/20 0.34
GLA P06280 1/20 0.34
HSD17B10 Q99714 1/20 0.34
DAO P14920 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5414986 0.87 MAPT (0.35) MAPTMEN1KMT2AKDM4EPABPC1
SCHEMBL3606545 0.81 KCNK3 (0.40) KMT2AKDM4EL3MBTL1ALDH1A1HSD17B10
SCHEMBL38661865 0.80 ALDH1A1 (0.41) MAPTLMNAL3MBTL1GAAALDH1A1
SCHEMBL10735199 0.80 ALDH1A1 (0.41) MAPTLMNAL3MBTL1GAAALDH1A1
SCHEMBL10719372 0.78 SMN1; SMN2 (0.32) MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL29469914 0.76 CA12 (0.47) MAPTMEN1KMT2AKDM4EPABPC1
SCHEMBL5410962 0.76 ALDH1A1 (0.41) MAPTMEN1KMT2AKDM4EPABPC1
SCHEMBL3598362 0.76 CA12 (0.47) MAPTMEN1KMT2AKDM4EPABPC1
SCHEMBL7026493 0.76 TSHR (0.49) MAPTMEN1KMT2AKDM4ETDP1
SCHEMBL10962433 0.75 TSHR (0.34) MAPTMEN1KMT2AKDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7723266-B2 Substituted aryl sulphony(thio)ureas used as herbicides BAYER AKTIENGESELLSCHAFT (DE) 2010-05-25 US disclosed
US-7723266-B2 Substituted aryl sulphony(thio)ureas used as herbicides BAYER AKTIENGESELLSCHAFT (DE) 2010-05-25 US disclosed
EP-0885200-B1 SUBSTITUTED ARYL SULPHONYL(THIO)UREAS USED AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2008-05-21 EP disclosed
US-RE39607-E1 Herbicidal sulphonylamino(thio) carbonyl compounds BAYER AKTIENGESELLSCHAFT (DE) 2007-05-01 US disclosed
US-RE39607-E1 Herbicidal sulphonylamino(thio) carbonyl compounds BAYER AKTIENGESELLSCHAFT (DE) 2007-05-01 US disclosed
EP-1683789-A1 Substituted arylsulfonyl(thio)ureas as herbicides Bayer CropScience AG (DE) 2006-07-26 EP disclosed
US-20050004123-A1 Substituted aryl sulphonyl(thio)ureas used as herbicides BAYER AG (DE) 2005-01-06 US disclosed
US-6838414-B2 Substituted aryl sulphonyl(thio)ureas used as herbicides BAYER AKTIENGESELLSCHAFT (DE) 2005-01-04 US disclosed
EP-1344771-A1 2-alkoxy-phenylsulphonic acid derivatives as intermediates for herbicidal sulphonylamino(thio)carbonyl compounds Bayer CropScience AG (DE) 2003-09-17 EP disclosed
EP-0842157-B1 HERBICIDAL SULPHONYLAMINO(THIO)CARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2003-08-27 EP disclosed
US-20030153463-A1 Substituted aryl sulphonyl(thio)ureas GESING ERNST RUDOLF F (DE) 2003-08-14 US disclosed
US-6525211-B1 Chemical intermediates BAYER AKTIENGESELLSCHAFT (DE) 2003-02-25 US disclosed
US-6451737-B1 N-(4,6-DIMETHYL-PYRIMIDIN-2-YL)-N'-(2-METHOXY-6-TRIFLUOROMETHY L-PHENYLSULPHONYL)-UREA BAYER AKTIENGESELLSCHAFT (DE) 2002-09-17 US disclosed
US-6251831-B1 WITH SUBSTITUTED PHENYL AND SUBSTITUTED 1,2,4-TRIAZOLE MOIETIES; PRE- AND POST-EMERGENCE HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-06-26 US disclosed
EP-0885200-A1 SUBSTITUTED ARYL SULPHONYL(THIO)UREAS USED AS HERBICIDES BAYER AG (DE) 1998-12-23 EP disclosed
EP-0842157-A1 HERBICIDAL SULPHONYLAMINO(THIO)CARBONYL COMPOUNDS BAYER AG (DE) 1998-05-20 EP disclosed
WO-1997032861-A1 SUBSTITUTED ARYL SULPHONYL(THIO)UREAS USED AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-09-12 WO disclosed
WO-1997003056-A1 HERBICIDAL SULPHONYLAMINO(THIO)CARBONYL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1997-01-30 WO disclosed
CN-87102275-A Selective herbicide and manufacturing thereof and use 1988-02-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030153463-A1 Substituted aryl sulphonyl(thio)ureas TST, DDT, CBR3 MAPT 4329/4885MEN1 4783/4885KMT2A 2029/4885
US-20050004123-A1 Substituted aryl sulphonyl(thio)ureas used as herbicides DDT, CBR3, TST MAPT 4114/4885MEN1 4796/4885KMT2A 1518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.