Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607029 | 1.00 | KDM4E (0.59) | KDM4ECYP1A2ALDH1A1CYP2C9HPGD | |
| SCHEMBL3596423 | 0.81 | KDM4E (0.59) | KDM4ECYP1A2HDAC1HDAC2ITGB3 | |
| SCHEMBL3596425 | 0.81 | KDM4E (0.59) | KDM4ECYP1A2HDAC1HDAC2ITGB3 | |
| SCHEMBL3320273 | 0.80 | MLLT1 (0.54) | KDM4ECYP1A2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3607328 | 0.80 | MLLT1 (0.54) | KDM4ECYP1A2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3320269 | 0.80 | MLLT1 (0.54) | KDM4ECYP1A2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL5114489 | 0.77 | KDM4E (0.75) | KDM4ECYP1A2ALDH1A1CYP2C9HPGD | |
| SCHEMBL3610362 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1PDGFRBPDGFRAHDAC1 | |
| SCHEMBL3610359 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1PDGFRBPDGFRAHDAC1 | |
| SCHEMBL24470565 | 0.76 | CASP3 (0.59) | KDM4EALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | KDM4E 963/4885CYP1A2 234/4885ALDH1A1 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.