Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 9/20 | 0.53 |
| ▸ | CDK8 | P49336 | 9/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 6/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598117 | 0.85 | CCNC (0.49) | CCNCCDK8ROCK2HASPINCDK19 | |
| SCHEMBL3588999 | 0.82 | CCNC (0.49) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL24744334 | 0.81 | ALDH1A1 (0.51) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL15005502 | 0.77 | ROCK2 (0.35) | CCNCCDK8ROCK2HASPINCDK19 | |
| SCHEMBL20747105 | 0.77 | CCNC (0.54) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL3593351 | 0.75 | MAP2K1 (0.46) | CCNCCDK8ROCK2ALDH1A1KDM4E | |
| SCHEMBL1005097 | 0.74 | CYP1A2 (0.49) | CCNCCDK8KDM4EGLAGAA | |
| SCHEMBL10142500 | 0.74 | GCGR (0.39) | AAK1 | |
| SCHEMBL3599560 | 0.70 | ROCK2 (0.47) | CCNCCDK8ROCK2HASPIN | |
| SCHEMBL18571896 | 0.69 | CCNC (0.75) | CCNCCDK8ROCK2HASPINCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118102-B1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-06-12 | — | — | EP | disclosed |
| US-8207180-B2 | Tricyclic indoles and (4,5-dihydro) indoles | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-26 | — | — | US | disclosed |
| US-20100075998-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075998-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | CDC7, CDK7, CDK17 | CCNC 19/4885CDK8 36/4885ROCK2 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.