Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.42 |
| ▸ | KHK | P50053 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598401 | 0.79 | CHRNA7 (0.54) | HTR4ACSS2CNR2 | |
| SCHEMBL3598403 | 0.79 | CHRNA7 (0.54) | HTR4ACSS2CNR2 | |
| Trifluoroacetic Acid SCHEMBL3606654 | 0.75 | KDR (0.52) | KDR | |
| Trifluoroacetic Acid SCHEMBL3601240 | 0.71 | KDM4E (0.49) | ACSS2KHKHDAC4KDRHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3602215 | 0.71 | KDM4E (0.49) | ACSS2KHKHDAC4KDRHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3599367 | 0.71 | HRH4 (0.47) | HDAC4HDAC6HRH4CDK4CDK2 | |
| Trifluoroacetic Acid SCHEMBL4259150 | 0.70 | HDAC4 (0.56) | HDAC4CHRNA1CHRNB2CHRNB4CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL3613494 | 0.70 | SMYD3 (0.61) | HDAC4HRH4HRH3CDK4CDK2 | |
| Trifluoroacetic Acid SCHEMBL3596233 | 0.70 | SMYD3 (0.61) | HDAC4HRH4HRH3CDK4CDK2 | |
| Trifluoroacetic Acid SCHEMBL29779140 | 0.70 | USP30 (0.50) | HDAC4HDAC6HRH4HRH3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | HTR4 247/4885ACSS2 2143/4885KHK 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.