Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.48 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163022 | 0.92 | MAPK1 (0.59) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| SCHEMBL28280152 | 0.92 | MAPK1 (0.59) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| SCHEMBL1163023 | 0.92 | MAPK1 (0.59) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| SCHEMBL7865237 | 0.88 | CHEK1 (0.55) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| Cadaverine Tartrate SCHEMBL28008723 | 0.84 | MAPK1 (0.52) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| SCHEMBL17927246 | 0.84 | HDAC4 (0.65) | HDAC4MAPK1OPRK1CHEK1CDK2AP1 | |
| SCHEMBL5230051 | 0.83 | MEN1 (0.54) | HDAC4MAPK1OPRK1 | |
| SCHEMBL8491815 | 0.83 | MEN1 (0.54) | HDAC4MAPK1OPRK1 | |
| SCHEMBL1250846 | 0.83 | MEN1 (0.54) | HDAC4MAPK1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL4252310 | 0.83 | ALDH1A1 (0.52) | HDAC4MAPK1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044055-A2 | AMIDE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008011131-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |