Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3616688 | 0.90 | HDAC8 (0.41) | HDAC8 | |
| SCHEMBL3608301 | 0.84 | GHSR (0.38) | HDAC8 | |
| SCHEMBL3603138 | 0.80 | HDAC8 (0.48) | HDAC8PTPN1 | |
| SCHEMBL3616692 | 0.75 | PPARA (0.32) | — | |
| SCHEMBL3615681 | 0.72 | HDAC8 (0.37) | HDAC8PTPN1 | |
| SCHEMBL3608110 | 0.69 | GHSR (0.39) | HDAC8 | |
| SCHEMBL3612561 | 0.66 | GHSR (0.44) | — | |
| SCHEMBL3597442 | 0.66 | GHSR (0.42) | — | |
| SCHEMBL7743681 | 0.65 | PTPN1 (0.54) | HDAC8PTPN1 | |
| SCHEMBL7743679 | 0.65 | PTPN1 (0.54) | HDAC8PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | HDAC8 375/4885PTPN1 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.