Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924925 | 0.92 | KDM4E (0.46) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3924309 | 0.87 | KDM4E (0.46) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3603742 | 0.82 | NOS1 (0.41) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3612784 | 0.82 | NOS1 (0.42) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3603747 | 0.81 | NOS1 (0.41) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3921216 | 0.80 | MAP4K4 (0.56) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3613666 | 0.79 | PDE4A (0.45) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4523926 | 0.79 | NOS1 (0.44) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL3612640 | 0.78 | NOS1 (0.41) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4114382 | 0.77 | KDM4E (0.45) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048559-A1 | PYRIDO(3,2-d)PYRIDMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | Gilead Science, Inc (US) | 2010-02-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048559-A1 | PYRIDO(3,2-d)PYRIDMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, PLPBP, PDXK | KDM4E 2887/4885NPC1 2663/4885ALDH1A1 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.