⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31216760 | 0.74 | EGFR (0.37) | — | |
| SCHEMBL127479 | 0.73 | EGFR (0.50) | — | |
| SCHEMBL28003243 | 0.70 | EGFR (0.48) | — | |
| SCHEMBL11242046 | 0.66 | PIM1 (0.37) | — | |
| SCHEMBL5052066 | 0.65 | LMNA (0.33) | — | |
| SCHEMBL7771 | 0.65 | — | — | |
| SCHEMBL31317325 | 0.64 | HPGDS (0.42) | — | |
| SCHEMBL13841392 | 0.64 | — | — | |
| SCHEMBL31019286 | 0.64 | PIM1 (0.32) | — | |
| SCHEMBL20303199 | 0.64 | DYRK1A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 435 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186578-B2 | Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors | SHENZHEN TARGETRX, INC. (CN) | 2021-11-30 | — | — | US | claimed |
| EP-2589601-B1 | COMPOUND FOR INHIBITING TYPE 5 PHOSPHODIESTERASE AND PREPARATION METHOD THEREOF | SUZHOU MAIDIXIAN PHARMACEUTICAL INC (CN) | 2015-09-09 | — | — | EP | claimed |
| EP-2589601-A1 | COMPOUND FOR INHIBITING TYPE 5 PHOSPHODIESTERASE AND PREPARATION METHOD THEREOF | Suzhou Maidixian Pharmaceutical Inc. (CN) | 2013-05-08 | — | — | EP | claimed |
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | claimed |
| EP-1475094-B1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2010-07-28 | — | — | EP | claimed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | claimed |
| EP-1620437-B1 | 5,7-DIAMINOPYRAZOLO¬4,3-D PYRIMIDINES USEFUL IN THE TRAETMENT OF HYPERTENSION | PFIZER LTD (GB) | 2009-06-17 | — | — | EP | claimed |
| US-20070270412-A1 | NOVEL PHARMACEUTICALS | PFIZER INC | 2007-11-22 | — | — | US | claimed |
| EP-1814885-A2 | NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-08-08 | — | — | EP | claimed |
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2007-07-19 | — | — | US | claimed |
| WO-2003082872-A1 | NOVEL PYRAZOLO[4,3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS FOR THERAPY | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC) (CZ) | 2003-10-09 | — | — | WO | claimed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | claimed |
| EP-1177797-A9 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-15 | — | — | EP | claimed |
| EP-1177797-A1 | NOVEL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-06 | — | — | EP | claimed |
| EP-0378483-B1 | Use of 4-mercapto-6-hydroxy-pyrazolo-(4,3-d)-pyrimidine as a scavenger of free radicals | BOUCHARA SA (FR) | 1996-08-14 | — | — | EP | claimed |
| US-4746663-A | Pyrazolo[4,3-d]pyrimidine derivative, process for its production, and antihyperlipidemic or antiatherosclerotic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1988-05-24 | — | — | US | claimed |
| US-4654348-A | Pyrazolo[4,3-d]pyrimidine derivative, process for its production, antihyperlipidemic agent containing it, its intermediate, and process for the production of the intermediate | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1987-03-31 | — | — | US | claimed |
| EP-0210653-A2 | Pyrazolo [4,3-d] pyrimidine derivative, process for its production, and antihyperlipidemic or antiatheroschlerotic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1987-02-04 | — | — | EP | claimed |
| EP-0157415-A2 | Pyrazolo[4,3-d] pyrimidine derivative process for its production antihyperlipidemic agent containing it, its intermediate, and process for the production of the intermediate | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1985-10-09 | — | — | EP | claimed |
| EP-0095289-A2 | Imidazo(1,2-c)pyrazolo(3,4-e)pyrimidines and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | claimed |