Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11532887 | 0.89 | PARP1 (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL14543827 | 0.89 | PARP1 (0.62) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29958262 | 0.89 | GAA (0.63) | MEN1KMT2AGAAPOLBCASP6 | |
| SCHEMBL29958428 | 0.89 | GAA (0.63) | MEN1KMT2AGAAPOLBCASP6 | |
| SCHEMBL12015108 | 0.85 | PARP1 (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29586144 | 0.85 | PARP1 (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL384204 | 0.82 | EGFR (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL14543826 | 0.81 | PARP1 (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL26445172 | 0.81 | CDK4 (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4231006 | 0.80 | GAA (0.67) | MEN1KMT2AGAAPOLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170144974-A1 | ACRIDONE COMPOUNDS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-05-25 | — | — | US | disclosed |
| US-9399625-B2 | Acridone compounds | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-07-26 | — | — | US | disclosed |
| US-20150210645-A1 | Acridone Compounds | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DBA THE DEPARTMENT OF VETERANS AFFAIRS | 2015-07-30 | — | — | US | disclosed |
| US-8987296-B2 | Acridone compounds | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140128423-A1 | Acridone Compounds | Government of the United States of America dba The Department of Veterans Affairs (US) | 2014-05-08 | — | — | US | disclosed |
| US-8592447-B2 | Acridone compounds | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2013-11-26 | — | — | US | disclosed |
| US-20100069428-A1 | ACRIDONE COMPOUNDS | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2010-03-18 | — | — | US | disclosed |
| WO-2008064011-A1 | ACRIDONE COMPOUNDS | THE GOVERNMENT OF THE U.S. OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210645-A1 | Acridone Compounds | ABCC1, ACR, NAT1 | GRIN2D 290/4885GRIN3B 223/4885GRIN1 10/4885 |
| US-20100069428-A1 | ACRIDONE COMPOUNDS | ACR, ABCC1, SLC11A2 | GRIN2D 127/4885GRIN3B 71/4885GRIN1 31/4885 |
| US-20170144974-A1 | ACRIDONE COMPOUNDS | ACR, ABCC1, SLC11A2 | GRIN2D 127/4885GRIN3B 71/4885GRIN1 31/4885 |
| US-20140128423-A1 | Acridone Compounds | ACR, ABCC1, SLC11A2 | GRIN2D 127/4885GRIN3B 71/4885GRIN1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.