Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.43 |
| ▸ | AKT1 | P31749 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610066 | 0.80 | PIK3CA (0.38) | PIK3CAAKT1MTORPIK3C3ALDH1A1 | |
| SCHEMBL3608929 | 0.65 | HTR6 (0.49) | PIK3CAAKT1MTORPIK3C3PIK3CB | |
| SCHEMBL26027490 | 0.61 | PIK3CA (0.58) | PIK3CAAKT1MTORPIK3C3ALDH1A1 | |
| SCHEMBL3600627 | 0.61 | MAPT (0.61) | PIK3CAMEN1CYP1A2KMT2AKDM4E | |
| SCHEMBL21464162 | 0.61 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3ALDH1A1 | |
| SCHEMBL29923078 | 0.61 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3ALDH1A1 | |
| SCHEMBL21464219 | 0.60 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL29923007 | 0.60 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL21464528 | 0.60 | PIK3CA (0.61) | PIK3CAAKT1MTORPIK3C3ALDH1A1 | |
| SCHEMBL30826822 | 0.60 | PIK3CA (0.61) | PIK3CAAKT1MTORPIK3C3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256143-A1 | PHARMACEUTICAL COMPOUNDS | BAKER STEWART JAMES | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256143-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, PIK3CD, JAK2 | PIK3CA 1/4885AKT1 41/4885MTOR 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.