Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.58 |
| ▸ | MTOR | P42345 | 3/20 | 0.58 |
| ▸ | AKT1 | P31749 | 2/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21464528 | 0.81 | PIK3CA (0.61) | PIK3CAMTORAKT1PIK3C3PKM | |
| SCHEMBL30826822 | 0.81 | PIK3CA (0.61) | PIK3CAMTORAKT1PIK3C3PKM | |
| SCHEMBL7137232 | 0.78 | HTR6 (0.67) | PIK3CAMTORAKT1PIK3C3PKM | |
| SCHEMBL26027776 | 0.76 | PIK3CA (0.65) | PIK3CAMTORAKT1PIK3C3ALDH1A1 | |
| SCHEMBL26027646 | 0.76 | PIK3CA (0.58) | PIK3CAMTORAKT1PKMTSHR | |
| SCHEMBL4791302 | 0.75 | MTOR (0.64) | PIK3CAMTORAKT1PKMALDH1A1 | |
| SCHEMBL10272785 | 0.74 | KMT2A (0.75) | PIK3CAMTORTSHRALDH1A1MEN1 | |
| SCHEMBL29923007 | 0.74 | PIK3CA (1.00) | PIK3CAMTORAKT1PIK3C3 | |
| SCHEMBL21464219 | 0.74 | PIK3CA (1.00) | PIK3CAMTORAKT1PIK3C3 | |
| SCHEMBL12110343 | 0.73 | KMT2A (0.51) | AKT1PKMTSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885MTOR 4/4885AKT1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.