Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.61 |
| ▸ | AKT1 | P31749 | 4/20 | 0.61 |
| ▸ | MTOR | P42345 | 2/20 | 0.61 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30826822 | 1.00 | PIK3CA (0.61) | PIK3CAAKT1MTORPIK3C3PKM | |
| SCHEMBL30826840 | 0.82 | PIK3CA (0.61) | PIK3CAAKT1MTORPKMTSHR | |
| SCHEMBL21464184 | 0.82 | PIK3CA (0.61) | PIK3CAAKT1MTORPKMTSHR | |
| SCHEMBL26027490 | 0.81 | PIK3CA (0.58) | PIK3CAAKT1MTORPIK3C3PKM | |
| SCHEMBL21464219 | 0.77 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL29923007 | 0.77 | PIK3CA (1.00) | PIK3CAAKT1MTORPIK3C3 | |
| SCHEMBL17397961 | 0.76 | HTR6 (0.58) | PIK3CAPIK3C3PKMKMT2AMEN1 | |
| SCHEMBL21464301 | 0.76 | MAPT (0.51) | PKMTSHRKMT2ACYP1A2MEN1 | |
| SCHEMBL7136700 | 0.76 | HTR6 (0.71) | PIK3CAAKT1MTORPIK3C3PKM | |
| SCHEMBL30826792 | 0.74 | PIK3CA (0.61) | PIK3CAAKT1MTORPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12637450-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | GLOBAL CANCER TECHNOLOGY INC. (US) | 2026-05-26 | — | — | US | disclosed |
| EP-3774783-B1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES INC (US) | 2025-06-04 | — | — | EP | disclosed |
| US-20240327396-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2024-10-03 | — | — | US | disclosed |
| US-12049462-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | NEUROPORE THERAPIES, INC. (US) | 2024-07-30 | — | — | US | disclosed |
| CN-112533917-B | Morpholine derivatives as inhibitors of VPS34 | 神经孔疗法股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-112189012-B | Trisubstituted aryl and heteroaryl derivatives as modulators of PI3 kinase and autophagy pathways | 神经孔疗法股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | NEUROPORE THERAPIES, INC. (US) | 2022-11-08 | — | — | US | disclosed |
| EP-3774792-B1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES INC (US) | 2022-09-14 | — | — | EP | disclosed |
| US-20210163462-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210163462-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| CN-112533917-A | Morpholine derivatives as inhibitors of VPS34 | 神经孔疗法股份有限公司 | 2021-03-19 | — | — | CN | disclosed |
| EP-3774792-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | Neuropore Therapies, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3774783-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | Neuropore Therapies, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| CN-112189012-A | Trisubstituted aryl and heteroaryl derivatives as modulators of PI3 kinase and autophagy pathways | 神经孔疗法股份有限公司 | 2021-01-05 | — | — | CN | disclosed |
| WO-2019199874-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2019199874-A1 | MORPHOLINE DERIVATES AS INHIBITORS OF VPS34 | NEUROPORE THERAPIES, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2019199864-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
| WO-2019199864-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | NEUROPORE THERAPIES, INC. (US) | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492348-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
| US-20210163462-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
| US-12637450-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | PIK3R4, PIK3R1, ATG7 | PIK3CA 52/4885AKT1 32/4885MTOR 10/4885 |
| US-20240327396-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
| US-12049462-B2 | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 5/4885 |
| US-20230265086-A1 | TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS | ATG7, ULK1, BECN1 | PIK3CA 31/4885AKT1 34/4885MTOR 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.