Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CENPE | Q02224 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772000 | 0.93 | CENPE (0.37) | NPC1CENPERORCKIFC1MAPT | |
| SCHEMBL4767596 | 0.85 | CENPE (0.44) | NPC1CENPEKIFC1MAPTS1PR1 | |
| SCHEMBL4774663 | 0.76 | CENPE (0.44) | CENPEKIFC1MAPTTP53S1PR1 | |
| SCHEMBL13161547 | 0.76 | CENPE (0.46) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL14031344 | 0.76 | CENPE (0.46) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL3463338 | 0.76 | CENPE (0.46) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL3461552 | 0.75 | CENPE (0.47) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL13161799 | 0.75 | CENPE (0.47) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL14870670 | 0.75 | CENPE (0.43) | NPC1CENPERORCKIFC1S1PR1 | |
| SCHEMBL3224699 | 0.75 | CENPE (0.45) | NPC1CENPERORCKIFC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582682-A1 | METHODS OF TREATING LUNG DISEASE | Cytokinetics, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2012009097-A1 | METHODS OF TREATING LUNG DISEASE | CYTOKINETICS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |