Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.44 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774049 | 0.79 | CENPE (0.37) | CENPEKIFC1S1PR1CCR3MAP4K4 | |
| SCHEMBL4767596 | 0.79 | CENPE (0.44) | CENPEKIFC1S1PR1CCR3MAP4K4 | |
| SCHEMBL13707933 | 0.78 | CENPE (0.59) | CENPEKIFC1TP53ALDH1A1MAPT | |
| SCHEMBL361204 | 0.76 | NPC1 (0.38) | CENPEKIFC1S1PR1CCR3TP53 | |
| SCHEMBL4772000 | 0.75 | CENPE (0.37) | CENPEKIFC1S1PR1S1PR3S1PR5 | |
| SCHEMBL4520166 | 0.74 | CENPE (0.55) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL13161557 | 0.71 | CENPE (0.52) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL13161775 | 0.71 | CENPE (0.52) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL3463128 | 0.71 | CENPE (0.52) | CENPEKIFC1S1PR1MAP4K4MINK1 | |
| SCHEMBL4774986 | 0.71 | CENPE (0.50) | CENPES1PR1S1PR3S1PR5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |