Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361204 | 0.93 | NPC1 (0.38) | CENPENPC1MAPTKIFC1TP53 | |
| SCHEMBL4767596 | 0.79 | CENPE (0.44) | CENPENPC1MAPTKIFC1S1PR1 | |
| SCHEMBL13161839 | 0.76 | CENPE (0.46) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL2103734 | 0.76 | CENPE (0.46) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL4774663 | 0.75 | CENPE (0.44) | CENPEMAPTKIFC1TP53S1PR1 | |
| SCHEMBL14031344 | 0.73 | CENPE (0.46) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL3463338 | 0.73 | CENPE (0.46) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL13161547 | 0.73 | CENPE (0.46) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL3461552 | 0.72 | CENPE (0.47) | CENPENPC1KIFC1RORCS1PR1 | |
| SCHEMBL13161799 | 0.72 | CENPE (0.47) | CENPENPC1KIFC1RORCS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742907-A4 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1742907-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005107762-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2005-11-17 | — | — | WO | disclosed |