Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 11/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.42 |
| ▸ | PLK1 | P53350 | 6/20 | 0.42 |
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13503001 | 0.87 | STK17A (0.48) | MAOBGRM5CHEK1FLT3 | |
| SCHEMBL3611480 | 0.85 | SIRT5 (0.46) | SIRT5CDK2CCNA2CCNA1PLK1 | |
| SCHEMBL3609399 | 0.80 | SIRT5 (0.49) | SIRT5CDK2CCNA2AURKAMAPT | |
| SCHEMBL3605169 | 0.78 | CDK2 (0.51) | SIRT5CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL3602605 | 0.77 | CDK2 (0.50) | SIRT5CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL3608990 | 0.77 | MAPT (0.52) | SIRT5CDK2CCNA2KDM4EMAPT | |
| SCHEMBL3611125 | 0.76 | MAPT (0.52) | SIRT5CDK2CCNA2KDM4EMAPT | |
| SCHEMBL3611150 | 0.76 | CDK2 (0.50) | SIRT5CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL3610608 | 0.75 | CDK1 (0.56) | SIRT5CDK2CCNA2CCNA1AURKA | |
| SCHEMBL3609176 | 0.75 | CDK2 (0.49) | SIRT5CDK2CCNA2CCNA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048597-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | SIRT5 2556/4885CDK2 3078/4885CCNA2 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.