Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617356 | 0.90 | MAPT (0.53) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL4600433 | 0.87 | ALDH1A1 (0.51) | KDM4EALDH1A1POLBHPGDIDO1 | |
| SCHEMBL15362051 | 0.84 | TP53 (0.35) | KDM4ESMN1; SMN2MAPTALDH1A1HTT | |
| SCHEMBL3566593 | 0.83 | IDO1 (0.58) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL832502 | 0.80 | NOD2 (0.57) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL3620717 | 0.79 | KDM4E (0.44) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL7751603 | 0.79 | NOD2 (0.50) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL21647437 | 0.78 | KDM4E (0.49) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL3566463 | 0.78 | NOD2 (0.49) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 | |
| SCHEMBL3619269 | 0.77 | NOD2 (0.51) | KDM4ESMN1; SMN2CRHBPCRHR2NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | claimed |
| US-20130046095-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | DUBOIS LAURENT (FR) | 2013-02-21 | — | — | US | claimed |
| US-20100222368-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-09-02 | — | — | US | claimed |
| US-20080146646-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222368-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | KDM4E 1499/4885SMN1; SMN2 2075/4885CRHBP 3524/4885 |
| US-20130046095-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | KDM4E 1499/4885SMN1; SMN2 2075/4885CRHBP 3524/4885 |
| US-20080146646-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | KDM4E 1499/4885SMN1; SMN2 2075/4885CRHBP 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.