Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 6/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599937 | 0.89 | CCR2 (0.63) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL3615596 | 0.87 | KDM4E (0.45) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL13802523 | 0.82 | CCR2 (0.62) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL15362051 | 0.79 | TP53 (0.35) | ALDH1A1KDM4EHPGDHSD17B10IDO1 | |
| SCHEMBL4599686 | 0.79 | IDO1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL4600294 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL12466547 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL3617356 | 0.76 | MAPT (0.53) | ALDH1A1KDM4EHPGDCCR2POLB | |
| SCHEMBL4599709 | 0.76 | CCR2 (0.55) | ALDH1A1KDM4EHPGDHSD17B10CCR2 | |
| SCHEMBL2895007 | 0.75 | CCR2 (0.70) | ALDH1A1KDM4EHPGDHSD17B10CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007010144-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2007-01-25 | — | — | WO | claimed |