Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20017671 | 0.75 | CLK1 (0.58) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL10305052 | 0.75 | ATR (0.50) | MAPTALDH1A1KDM4EHSD17B10KDR | |
| SCHEMBL27361882 | 0.74 | CLK1 (0.59) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL14406351 | 0.73 | SSTR2 (0.57) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL822535 | 0.73 | CLK1 (0.49) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL2581392 | 0.72 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL25034156 | 0.72 | MAPT (0.57) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL25034155 | 0.70 | PDGFRB (0.57) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL4398433 | 0.69 | MAPT (0.62) | CLK1CDK5CDK5R1GSK3BDYRK1A | |
| SCHEMBL29488162 | 0.69 | GSK3B (1.00) | CLK1CDK5CDK5R1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048596-A2 | Indole Derivatives as Antitumoral Compounds | PHARMA MAR, S.A. (ES) | 2010-02-25 | — | — | US | disclosed |
| US-20090124647-A1 | Indole Derivatives as Antitumoral Compounds | PHARMA MAR, S.A. (ES) | 2009-05-14 | — | — | US | disclosed |
| EP-1951711-A1 | INDOLE DERIVATIVES AS ANTITUMOURAL COMPOUNDS | Pharma Mar, S.A. (ES) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007054748-A1 | INDOLE DERIVATIVES AS ANTITUMOURAL COMPOUNDS | PHARMA MAR, S.A. (ES) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124647-A1 | Indole Derivatives as Antitumoral Compounds | NPR3, IDO1, ADORA3 | CLK1 3221/4885CDK5 1324/4885CDK5R1 1300/4885 |
| US-20100048596-A2 | Indole Derivatives as Antitumoral Compounds | NPR3, IDO1, ADORA3 | CLK1 3221/4885CDK5 1324/4885CDK5R1 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.