Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3620900 | 1.00 | ADRB1 (0.41) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL5135381 | 1.00 | ADRB1 (0.41) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL13807457 | 0.90 | ADRB2 (0.35) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL3714998 | 0.89 | ADRB2 (0.36) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL3714996 | 0.89 | ADRB2 (0.36) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL3627413 | 0.88 | RAB9A (0.36) | ADRB1SLC6A3CYP2D6HTR1ASLC6A2 | |
| SCHEMBL3627411 | 0.88 | RAB9A (0.36) | ADRB1SLC6A3CYP2D6HTR1ASLC6A2 | |
| SCHEMBL4386734 | 0.82 | MRGPRX4 (0.40) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL4386737 | 0.82 | MRGPRX4 (0.40) | ADRB1CYP3A4USP2SLC6A4ADRA1A | |
| SCHEMBL3628398 | 0.82 | ADRB2 (0.47) | ADRB1CYP3A4USP2SLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730103-B1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | PFIZER LTD (GB) | 2010-05-26 | — | — | EP | disclosed |
| US-7547731-B2 | Formamide derivatives for the treatment of diseases | PFIZER INC (US) | 2009-06-16 | — | — | US | disclosed |