Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627755 | 0.84 | MIF (0.67) | ALDH1A1MAPTHPGDMIFPOLB | |
| SCHEMBL3625862 | 0.80 | SNRNP200 (0.50) | ALDH1A1MAPTHTR6MAPK1HTT | |
| SCHEMBL3544385 | 0.79 | MIF (0.44) | ALDH1A1MAPTHPGDMIFPOLB | |
| SCHEMBL2767357 | 0.77 | NPC1 (0.59) | ALDH1A1MAPTMIFPOLBLMNA | |
| SCHEMBL29158165 | 0.76 | MGLL (0.42) | ALDH1A1MAPTHPGDPOLBGAA | |
| SCHEMBL29158160 | 0.76 | MGLL (0.42) | ALDH1A1MAPTHPGDPOLBGAA | |
| SCHEMBL2784276 | 0.75 | POLB (0.41) | ALDH1A1MAPTHPGDPOLBMEN1 | |
| SCHEMBL3626605 | 0.75 | MGLL (0.41) | ALDH1A1MGLLDRD2KMT2AHTR6 | |
| SCHEMBL28631579 | 0.75 | GAA (0.61) | ALDH1A1MAPTHPGDPOLBGAA | |
| SCHEMBL2784147 | 0.73 | NPC1 (0.51) | ALDH1A1MAPTHPGDMIFGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795251-B2 | 3,4-dihydro-benzo[e][1,3]oxazin-2-ones | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | disclosed |
| EP-1874742-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | Novartis AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108671-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |