Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNRNP200 | O75643 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622244 | 0.80 | ALDH1A1 (0.49) | HTR6MAOBMAPTMAPK1ALDH1A1 | |
| SCHEMBL3625864 | 0.80 | MAOA (0.44) | SLC6A2SLC6A3HIF1AMAOBMAPT | |
| SCHEMBL3626605 | 0.73 | MGLL (0.41) | HTR1AHTR6MAOBMAPK1MAOA | |
| SCHEMBL2784147 | 0.72 | NPC1 (0.51) | HTR1AMAOBMAPTTDP1MAOA | |
| SCHEMBL2784276 | 0.70 | POLB (0.41) | HTR1AHTR6MAPTTDP1ALDH1A1 | |
| SCHEMBL27714988 | 0.69 | HTR1A (0.55) | SNRNP200HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2783566 | 0.68 | DRD3 (0.46) | MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL28519652 | 0.68 | MAPT (0.46) | HTR1AMAOBMAPTMAPK1TDP1 | |
| SCHEMBL2767899 | 0.67 | TSHR (0.45) | HTR1AMAOBMAOAHTT | |
| SCHEMBL7358848 | 0.66 | SNRNP200 (0.51) | SNRNP200HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795251-B2 | 3,4-dihydro-benzo[e][1,3]oxazin-2-ones | NOVARTIS AG (CH) | 2010-09-14 | — | — | US | disclosed |
| EP-1874742-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | Novartis AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006108671-A1 | 3,4-DIHYDRO-BENZO[E][1,3]OXAZIN-2-ONES | NOVARTIS AG (CH) | 2006-10-19 | — | — | WO | disclosed |