Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 3/20 | 0.41 |
| ▸ | GUCY1A2 | P33402 | 3/20 | 0.41 |
| ▸ | GUCY1A1 | Q02108 | 3/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 3/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628788 | 0.92 | KMT2A (0.45) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3625792 | 0.90 | LMNA (0.38) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3629056 | 0.87 | GUCY1B2 (0.45) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3627162 | 0.86 | PTGDR2 (0.43) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3620748 | 0.85 | EIF4EBP1 (0.38) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3627141 | 0.85 | SYK (0.38) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3627858 | 0.84 | GUCY1B2 (0.44) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3627113 | 0.84 | GUCY1B2 (0.44) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3624510 | 0.83 | CCR5 (0.42) | LMNAKDM4EMEN1USP2TSHR | |
| SCHEMBL3626707 | 0.81 | MEN1 (0.48) | KDM4EMEN1TSHRKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |