Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623230 | 1.00 | MAPK1 (0.33) | MAPK1P2RX7 | |
| SCHEMBL3623316 | 0.87 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL5126234 | 0.87 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL3627713 | 0.87 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL2579829 | 0.87 | P2RX7 (0.36) | P2RX7 | |
| SCHEMBL4513877 | 0.86 | L3MBTL1 (0.34) | MAPK1P2RX7 | |
| SCHEMBL2577904 | 0.84 | P2RX7 (0.33) | P2RX7 | |
| SCHEMBL4514655 | 0.82 | TSHR (0.42) | MAPK1 | |
| SCHEMBL2584768 | 0.80 | RIPK1 (0.31) | P2RX7 | |
| SCHEMBL4513488 | 0.80 | P2RX7 (0.32) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737141-B2 | such as -{4-{1-[(S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-(3E)-ylidenemethyl}-2-methoxyphenyl}-5-methyl-1-(phosphonooxymethyl)-3H-imidazol-1-ium trifluoroacetate, which inhibit the synthesis of amyloid precursor proteins; treatment of Alzheimer's disease, Down syndrome or amyloidosis | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-06-15 | — | — | US | disclosed |
| EP-2048143-A1 | PRODRUG OF CINNAMIDE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| US-20090048213-A1 | Prodrug of cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048213-A1 | Prodrug of cinnamide compound | BTK, CNKSR1, AKT1 | MAPK1 1605/4885P2RX7 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.