Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 12/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340203 | 0.86 | HTR6 (0.54) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3337575 | 0.83 | HTR6 (0.51) | PKMNPC1PKLRRAB9AHTR6 | |
| SCHEMBL3625114 | 0.81 | NR3C2 (0.44) | PKMRAB9AHTR6HTR1ADRD2 | |
| SCHEMBL3334361 | 0.81 | HTR6 (0.53) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3624153 | 0.80 | HTR6 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3621987 | 0.79 | HTR6 (0.46) | PKMNPC1PKLRRAB9AHTR6 | |
| SCHEMBL3621695 | 0.79 | HTR6 (0.42) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3621648 | 0.79 | HTR6 (0.39) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3335906 | 0.78 | HTR6 (0.50) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3624061 | 0.76 | AKR1C3 (0.46) | RAB9AHTR6HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184990-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009023844-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-02-19 | — | — | WO | disclosed |