Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.35 |
| ▸ | GLRB | P48167 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621695 | 0.84 | HTR6 (0.42) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3621648 | 0.82 | HTR6 (0.39) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3611501 | 0.81 | HTR6 (0.56) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3623951 | 0.80 | PKM (0.41) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3625114 | 0.78 | NR3C2 (0.44) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3624061 | 0.76 | AKR1C3 (0.46) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3621753 | 0.72 | HTR6 (0.61) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3617687 | 0.70 | HTR6 (0.35) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL13953734 | 0.67 | HTR6 (0.61) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3622224 | 0.67 | HTR6 (0.58) | HTR6HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184990-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2010-05-19 | — | — | EP | claimed |
| WO-2009023844-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-02-19 | — | — | WO | claimed |