Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624153 | 0.82 | HTR6 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3613339 | 0.82 | HTR6 (0.58) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3621695 | 0.81 | HTR6 (0.42) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Iodide SCHEMBL3622153 | 0.81 | HTR6 (0.57) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3624061 | 0.80 | AKR1C3 (0.46) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3623951 | 0.79 | PKM (0.41) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3625114 | 0.78 | NR3C2 (0.44) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Phosphoric Acid SCHEMBL3622110 | 0.78 | HTR6 (0.54) | HTR6HTR1ADRD2HTR2AHTR7 | |
| Phosphoric Acid SCHEMBL27788132 | 0.78 | HTR6 (0.54) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL3615737 | 0.77 | HTR6 (0.59) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184990-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009023844-A2 | 3' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-02-19 | — | — | WO | disclosed |