Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622064 | 0.86 | HSP90AA1 (0.52) | HSP90AA1NPC1MEN1RAB9AKMT2A | |
| SCHEMBL3621474 | 0.84 | NPC1 (0.48) | HSP90AA1NPC1RAB9AHTTKDM4E | |
| SCHEMBL3611841 | 0.84 | MMP13 (0.52) | HSP90AA1RAB9AHPGDHTTKDM4E | |
| SCHEMBL3619209 | 0.84 | PLA2G1B (0.46) | NPC1MEN1RAB9AKMT2AHPGD | |
| SCHEMBL3619650 | 0.79 | HSP90AA1 (0.63) | HSP90AA1HSP90B1 | |
| SCHEMBL3613141 | 0.78 | KMT2A (0.55) | HSP90AA1NPC1RAB9AKMT2AHPGD | |
| SCHEMBL6362312 | 0.72 | HPGD (0.65) | NPC1HPGDHTTKDM4EPPARG | |
| SCHEMBL3619097 | 0.72 | EGFR (0.48) | NPC1MEN1RAB9AKMT2AHPGD | |
| SCHEMBL3618927 | 0.70 | NPC1 (0.43) | NPC1RAB9AHTTKDM4EALDH1A1 | |
| SCHEMBL3624720 | 0.69 | TSHR (0.48) | HSP90AA1NPC1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781485-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-24 | — | — | US | disclosed |
| US-20070265268-A1 | Hsp90 Family protein Inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1813270-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265268-A1 | Hsp90 Family protein Inhibitors | HSPA4L, HSP90AB1, HSP90B1 | HSP90AA1 4/4885NPC1 1764/4885MEN1 4809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.