Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 2/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25272684 | 0.98 | CHRM1 (0.51) | CHRM1RAB9AOPRD1SIGMAR1MAPK1 | |
| Hydrochloric Acid SCHEMBL25272683 | 0.98 | CHRM1 (0.51) | CHRM1RAB9AOPRD1SIGMAR1MAPK1 | |
| SCHEMBL21907373 | 0.86 | CHRM1 (0.56) | CHRM1RAB9AMAPK1KMT2AMEN1 | |
| SCHEMBL22188711 | 0.85 | RAB9A (0.41) | CHRM1RAB9AOPRD1SIGMAR1AURKA | |
| SCHEMBL13865331 | 0.84 | CHRM1 (0.55) | CHRM1RAB9AMAPK1KMT2AMEN1 | |
| SCHEMBL18390251 | 0.83 | CHRM1 (0.74) | CHRM1RAB9AMAPK1AURKAABL1 | |
| SCHEMBL12282147 | 0.82 | KMT2A (0.62) | CHRM1RAB9AMAPK1KMT2AMEN1 | |
| SCHEMBL18390271 | 0.81 | CHRM1 (0.60) | CHRM1RAB9AMAPK1KMT2AMEN1 | |
| SCHEMBL16207602 | 0.80 | SIGMAR1 (0.53) | CHRM1OPRD1SIGMAR1POLBKMT2A | |
| SCHEMBL16207601 | 0.80 | SIGMAR1 (0.53) | CHRM1OPRD1SIGMAR1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004252-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND/OR INHIBITION OF PAIN | GRUENENTHAL GMBH (DE) | 2010-01-07 | — | — | US | disclosed |
| US-7625900-B2 | Sutstituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain | GRUENENTHAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-20080167315-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain | GRUENENTHAL GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20050288347-A1 | Certain triazole-based compounds, compositions, and uses thereof | AGRIUS GROUP, LLC. | 2005-12-29 | — | — | US | disclosed |
| US-4775673-A | Substituted acylpiperazinoquinazolines and pharmaceutical compositions containing same | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CZ) | 1988-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288347-A1 | Certain triazole-based compounds, compositions, and uses thereof | ABCG2, ATP5ME, DNTT | CHRM1 4601/4885RAB9A 4278/4885OPRD1 4268/4885 |
| US-20100004252-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT AND/OR INHIBITION OF PAIN | KCNQ2, KCNQ1, KCNJ2 | CHRM1 1836/4885RAB9A 3709/4885OPRD1 227/4885 |
| US-20080167315-A1 | Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain | KCNQ2, KCNQ1, KCNJ2 | CHRM1 1836/4885RAB9A 3709/4885OPRD1 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.