Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3618173 | 1.00 | IRAK4 (0.37) | IRAK4CDC7PIM1CDK9PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3619396 | 0.99 | IRAK4 (0.38) | IRAK4CDC7PIM1CDK9PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3613213 | 0.92 | TBK1 (0.36) | IRAK4CDC7PIM1CDK9HRH4 | |
| Trifluoroacetic Acid SCHEMBL3618387 | 0.92 | CDC7 (0.38) | IRAK4CDC7PIM1CDK9MAPT | |
| SCHEMBL13408193 | 0.91 | PIM1 (0.42) | IRAK4CDC7PIM1CDK9PRKD1 | |
| SCHEMBL13408197 | 0.91 | PIM1 (0.42) | IRAK4CDC7PIM1CDK9PRKD1 | |
| SCHEMBL13408196 | 0.91 | PIM1 (0.43) | IRAK4CDC7PIM1CDK9PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3610696 | 0.90 | IRAK4 (0.42) | IRAK4CDC7PIM1CDK9PRKD1 | |
| Trifluoroacetic Acid SCHEMBL3614800 | 0.88 | IRAK4 (0.34) | IRAK4CDC7PIM1CDK9HRH4 | |
| Trifluoroacetic Acid SCHEMBL3620819 | 0.87 | CDK9 (0.41) | IRAK4CDC7PIM1CDK9PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | claimed |
| US-20100105664-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-04-29 | — | — | US | disclosed |
| EP-2069333-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | Novartis Ag (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105664-A1 | ORGANIC COMPOUNDS | SLCO1B3, SLCO1B1, SLC10A6 | IRAK4 3656/4885CDC7 4089/4885PIM1 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.