SCHEMBL3625530

SCHEMBL3625530

COc1ccc(CC=O)c(O)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.57
TRIM24 O15164 1/20 0.56
TYR P14679 1/20 0.56
TRIM33 Q9UPN9 1/20 0.56
ERN1 O75460 1/20 0.51
ESR1 P03372 1/20 0.51
CYP19A1 P11511 1/20 0.51
ESR2 Q92731 1/20 0.51
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
ALDH1A1 P00352 1/20 0.47
CYP3A4 P08684 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.44
APLNR P35414 1/20 0.43
MAPT P10636 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP1A1 P04798 1/20 0.42
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL874158 0.86 ERN1 (0.56) POLBTRIM24TYRTRIM33ERN1
SCHEMBL3396177 0.83 POLB (0.41) POLBTRIM24TYRTRIM33ERN1
SCHEMBL910548 0.83 POLB (0.62) POLBTRIM24TYRTRIM33ERN1
SCHEMBL4438747 0.83 LTA4H (0.44) ERN1NPC1RAB9AALDH1A1MAPT
SCHEMBL4438609 0.82 CHRM2 (0.47) POLBTRIM24TYRTRIM33ERN1
SCHEMBL2843664 0.82 PTPN1 (0.54) POLBTRIM24TYRTRIM33ESR1
SCHEMBL5137000 0.81 ESR2 (0.47) POLBTRIM24TYRTRIM33ERN1
SCHEMBL2045876 0.81 POLB (0.64) POLBTRIM24TYRTRIM33ERN1
SCHEMBL24805120 0.81 POLB (0.51) POLBTRIM24TYRTRIM33ESR1
SCHEMBL1613798 0.80 APLNR (0.62) ALDH1A1CYP3A4APLNRMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3703511-A2 VANILLA COMPOSITION Firmenich SA (CH) 2020-09-09 EP claimed
WO-2020065097-A2 VANILLA COMPOSITION FIRMENICH SA (CH) 2020-04-02 WO claimed
CN-116261399-A Citrus oil extract 弗门尼舍有限公司 2023-06-13 CN disclosed
EP-3703511-A2 VANILLA COMPOSITION Firmenich SA (CH) 2020-09-09 EP disclosed
CN-111526728-A Vanilla composition 弗门尼舍有限公司 2020-08-11 CN disclosed
EP-3687506-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2020-08-05 EP disclosed
WO-2020065097-A2 VANILLA COMPOSITION FIRMENICH SA (CH) 2020-04-02 WO disclosed
WO-2019195720-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2019-10-10 WO disclosed
WO-2017187321-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AbbVie S.à.r.l. (LU) 2017-11-02 WO disclosed
EP-3212189-A1 SUBSTITUTED CHROMANES AND METHOD OF USE AbbVie S.À.R.L. (LU) 2017-09-06 EP disclosed
WO-2016069757-A1 SUBSTITUTED CHROMANES AND METHOD OF USE ABBVIE INC. (US) 2016-05-06 WO disclosed
CN-102319184-B Parakeratosis inhibitor, pore-shrinking agent and external composition for skin SHISEIDO CO LTD 2015-03-25 CN disclosed
EP-2254878-A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION Gilead Palo Alto, Inc. (US) 2010-12-01 EP disclosed
EP-2231149-A2 ALDH-2 INHIBITORS IN THE TREATMENT OF PSYCHIATRIC DISORDERS CV Therapeutics Inc. (US) 2010-09-29 EP disclosed
WO-2009094028-A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION CV THERAPEUTICS, INC. (US) 2009-07-30 WO disclosed
WO-2009061924-A2 ALDH-2 INHIBITORS IN THE TREATMENT OF PSYCHIATRIC DISORDERS CV THERAPEUTICS, INC. (US) 2009-05-14 WO disclosed
EP-2046769-A2 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION CV THERAPEUTICS, INC. (US) 2009-04-15 EP disclosed
WO-2008076767-A1 CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF PURDUE RESEARCH FOUNDATION (US) 2008-06-26 WO disclosed
WO-2008014497-A2 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION CV THERAPEUTICS, INC. (US) 2008-01-31 WO disclosed
WO-1997040020-A1 PHTHALAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1997-10-30 WO disclosed