Sugi Predict

Sugi Predict / Compounds / SCHEMBL362563

SCHEMBL362563

SCHEMBL362563

COC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.39
▸ PDK2 Q15119 2/20 0.36
▸ CA1 P00915 2/20 0.36
▸ CA2 P00918 2/20 0.36
▸ MAPT P10636 2/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ NFKB1 P19838 1/20 0.35
▸ NFKB2 Q00653 1/20 0.35
▸ RELA Q04206 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ F2 P00734 3/20 0.34
▸ F10 P00742 3/20 0.34
▸ PRSS1 P07477 3/20 0.34
▸ PRF1 P14222 1/20 0.33
▸ ABL1 P00519 1/20 0.32
▸ NOTUM Q6P988 1/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23778641 1.00 KDM4E (0.39) KDM4EPDK2CA1CA2MAPT
SCHEMBL16688172 0.94 KDM4E (0.39) KDM4EPDK2CA1CA2MAPT
SCHEMBL1468195 0.92 KDM4E (0.37) KDM4EPDK2CA1CA2MAPT
SCHEMBL14958243 0.91 PDK2 (0.39) KDM4EPDK2CA1CA2MAPT
SCHEMBL2529138 0.91 PDK2 (0.45) KDM4EPDK2CA1CA2MAPT
SCHEMBL2539531 0.90 CA1 (0.35) KDM4ECA1CA2MAPTF2
SCHEMBL16680931 0.90 PDK2 (0.37) KDM4EPDK2CA1CA2MAPT
SCHEMBL1358620 0.90 KDM4E (0.33) KDM4EPDK2CA1CA2MAPT
SCHEMBL736544 0.90 HSD17B10 (0.37) KDM4EPDK2CA1CA2MAPT
SCHEMBL23778669 0.90 PDK2 (0.37) KDM4EPDK2CA1CA2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114539180-B Bisamide compound containing isoxazoline and preparation method and application thereof 贵州大学 2025-02-07 — — CN disclosed
CN-118930531-A Isoxazoline derivative and preparation method and application thereof 山东省联合农药工业有限公司 2024-11-12 — — CN disclosed
CN-118084890-A Isoxazoline-containing pyrazole amide compound as well as preparation method and application thereof 安徽农业大学 2024-05-28 — — CN disclosed
CN-117800930-A Preparation method of fluororalrana 杭州师范大学 2024-04-02 — — CN disclosed
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 — — US disclosed
CN-116640100-A Solid-phase synthesis method of fluororalrana 河北圣雪大成制药有限责任公司 2023-08-25 — — CN disclosed
CN-114957147-A Preparation method of isoxazoline derivatives 武汉工程大学 2022-08-30 — — CN disclosed
CN-114605324-A Isoxazoline substituted benzamide derivative and preparation method and application thereof 山东省联合农药工业有限公司 2022-06-10 — — CN disclosed
CN-114539180-A Isoxazoline-containing bisamide compound and preparation method and application thereof 贵州大学 2022-05-27 — — CN disclosed
CN-114380762-A Isoxazoline hydrazide derivative and preparation method and application thereof 贵州大学 2022-04-22 — — CN disclosed
WO-2010020522-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-02-25 — — WO disclosed
WO-2010020522-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-02-25 — — WO disclosed
US-7662972-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-16 — — US disclosed
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-12-17 — — US disclosed
WO-2009112275-A1 PESTICIDAL CONDENSED - RING ARYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2009-09-17 — — WO disclosed
WO-2009080250-A2 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2009-07-02 — — WO disclosed
WO-2009080250-A2 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2009-07-02 — — WO disclosed
WO-2008122375-A2 INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2008-10-16 — — WO disclosed
EP-1932836-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND HARMFUL ORGANISM-CONTROLLING AGENT Nissan Chemical Industries, Ltd. (JP) 2008-06-18 — — EP disclosed
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT KDM4E 1334/4885PDK2 445/4885CA1 1596/4885
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE ATM, CHRM1, NAT1 KDM4E 3394/4885PDK2 757/4885CA1 1945/4885
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly CHRM1, DDT, ATM KDM4E 3630/4885PDK2 1554/4885CA1 2192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.