Sugi Predict

Sugi Predict / Compounds / SCHEMBL16680931

SCHEMBL16680931

SCHEMBL16680931

COC(=O)c1ccc(C2=NOC(c3cc(Cl)c(F)c(Cl)c3)(C(F)(F)F)C2)cc1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ F2 P00734 2/20 0.33
▸ F10 P00742 2/20 0.33
▸ PRSS1 P07477 2/20 0.33
▸ CA1 P00915 2/20 0.33
▸ CA2 P00918 2/20 0.33
▸ NOTUM Q6P988 1/20 0.33
▸ PRF1 P14222 1/20 0.33
▸ SMN1; SMN2 Q16637 3/20 0.32
▸ NPC1 O15118 2/20 0.32
▸ RAB9A P51151 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ NFKB1 P19838 1/20 0.32
▸ NFKB2 Q00653 1/20 0.32
▸ RELA Q04206 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ CASP3 P42574 1/20 0.32
▸ SENP8 Q96LD8 1/20 0.32
▸ SENP7 Q9BQF6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23778669 1.00 PDK2 (0.37) PDK2KDM4EF2F10PRSS1
SCHEMBL14958243 0.93 PDK2 (0.39) PDK2KDM4EF2F10PRSS1
SCHEMBL14721680 0.91 MIF (0.33) KDM4ECA1CA2MAPTPDE3B
SCHEMBL14721679 0.91 MIF (0.33) KDM4ECA1CA2MAPTPDE3B
SCHEMBL30309340 0.91 NPC1 (0.36) PDK2KDM4EF10SMN1; SMN2NPC1
SCHEMBL24234496 0.90 KDM4E (0.35) PDK2KDM4EF2F10PRSS1
SCHEMBL23778641 0.90 KDM4E (0.39) PDK2KDM4EF2F10PRSS1
SCHEMBL362563 0.90 KDM4E (0.39) PDK2KDM4EF2F10PRSS1
SCHEMBL18669129 0.89 RXRA (0.35) CA1CA2PDE3BPDE3AIL2
SCHEMBL18670608 0.89 RXRA (0.35) CA1CA2PDE3BPDE3AIL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12564193-B2 Isoxazoline-substituted benzamide derivative, and preparation method therefor and use thereof SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD. (CN) 2026-03-03 — — US disclosed
EP-4159732-B1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANDONG UNITED PESTICIDE IND CO LTD (CN) 2025-10-15 — — EP disclosed
CN-118930531-A Isoxazoline derivative and preparation method and application thereof 山东省联合农药工业有限公司 2024-11-12 — — CN disclosed
WO-2024175572-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-08-29 — — WO disclosed
US-20230240298-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANDONG UNITED PESTICIDE INDUSTRY CO., LTD. (CN) 2023-08-03 — — US disclosed
EP-4159732-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shandong United Pesticide Industry Co., Ltd. (CN) 2023-04-05 — — EP disclosed
CN-114605324-A Isoxazoline substituted benzamide derivative and preparation method and application thereof 山东省联合农药工业有限公司 2022-06-10 — — CN disclosed
WO-2022022221-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 山东省联合农药工业有限公司 2022-02-03 — — WO disclosed
WO-2022022221-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 山东省联合农药工业有限公司 2022-02-03 — — WO disclosed
CN-111909143-B Isoxazoline substituted benzamide derivative and preparation method and application thereof 山东省联合农药工业有限公司 2021-10-29 — — CN disclosed
EP-3063144-B1 ANTIPARASITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2021-09-08 — — EP disclosed
CN-111909143-A Isoxazoline substituted benzamide derivative and preparation method and application thereof 山东省联合农药工业有限公司 2020-11-10 — — CN disclosed
EP-3733664-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS Boehringer Ingelheim Animal Health USA Inc. (US) 2020-11-04 — — EP disclosed
US-9447084-B2 Antiparisitic and pesticidal isoxazoline compounds MERIAL, INC. (US) 2016-09-20 — — US disclosed
US-9447084-B2 Antiparisitic and pesticidal isoxazoline compounds MERIAL, INC. (US) 2016-09-20 — — US disclosed
EP-3063144-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS Merial, Inc. (US) 2016-09-07 — — EP disclosed
US-20150126523-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS MERIAL LIMITED (US) 2015-05-07 — — US disclosed
US-20150126523-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS MERIAL LIMITED (US) 2015-05-07 — — US disclosed
WO-2015066277-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS MERIAL LIMITED (US) 2015-05-07 — — WO disclosed
WO-2015066277-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS MERIAL LIMITED (US) 2015-05-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12564193-B2 Isoxazoline-substituted benzamide derivative, and preparation method therefor and use thereof CYP4F11, CYP4Z1, CYP4X1 PDK2 1672/4885KDM4E 2883/4885F2 205/4885
US-20150126523-A1 ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS ACHE, PRDX1, CHRM1 PDK2 674/4885KDM4E 2875/4885F2 115/4885
US-20230240298-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF CYP51A1, WEE1, NOTUM PDK2 650/4885KDM4E 991/4885F2 2214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.