Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.55 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871647 | 0.89 | AKR1B1 (0.79) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9202242 | 0.89 | AKR1B1 (0.79) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL10065361 | 0.89 | AKR1B1 (0.61) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL361256 | 0.88 | AKR1B1 (0.71) | AKR1B1 | |
| SCHEMBL15217623 | 0.88 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Caficrestat SCHEMBL359604 | 0.88 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 | |
| Caficrestat SCHEMBL29444132 | 0.88 | AKR1B1 (0.81) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL21319726 | 0.87 | AKR1B1 (0.56) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL362133 | 0.86 | AKR1B1 (0.54) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL19139931 | 0.86 | AKR1B1 (0.55) | AKR1B1AKR1B10AKR1A1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238288-A1 | ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY | BARCLAYS BANK PLC (GB) | 2024-07-18 | — | — | US | disclosed |
| US-20240180907-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2024-06-06 | — | — | US | disclosed |
| US-20230346782-A1 | COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA | BARCLAYS BANK PLC (GB) | 2023-11-02 | — | — | US | disclosed |
| US-11730737-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-22 | — | — | US | disclosed |
| US-11730737-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-22 | — | — | US | disclosed |
| US-11730737-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-08-22 | — | — | US | disclosed |
| US-20230121312-A1 | ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY | Applied Therapeutics, Inc. | 2023-04-20 | — | — | US | disclosed |
| US-11590131-B2 | Compositions and methods for treating galactosemia | Applied Therapeutics, Inc. (US) | 2023-02-28 | — | — | US | disclosed |
| US-20230058134-A1 | ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY | BARCLAYS BANK PLC (GB) | 2023-02-23 | — | — | US | disclosed |
| EP-4124620-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2023-02-01 | — | — | EP | disclosed |
| US-20150072989-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-03-12 | — | — | US | disclosed |
| US-8916563-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916563-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916563-B2 | Aldose reductase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-12-23 | — | — | US | disclosed |
| US-20130225592-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-08-29 | — | — | US | disclosed |
| US-20130225592-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-08-29 | — | — | US | disclosed |
| US-20130225592-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-08-29 | — | — | US | disclosed |
| EP-2593456-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | The Trustees of Columbia University in the City of New York (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009553-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012009553-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11590131-B2 | Compositions and methods for treating galactosemia | GLA, ALDOA, GALC | AKR1B1 42/4885AKR1B10 159/4885AKR1A1 74/4885 |
| US-20240238288-A1 | ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY | SORD, SDHA, SDHB | AKR1B1 9/4885AKR1B10 27/4885AKR1A1 14/4885 |
| US-20240180907-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | AKR1B1 2/4885AKR1B10 8/4885AKR1A1 5/4885 |
| US-20230121312-A1 | ALDOSE REDUCTASE INHIBITORS FOR TREATING SORBITOL DEHYDROGENASE DEFICIENCY | SORD, SDHA, SDHB | AKR1B1 9/4885AKR1B10 27/4885AKR1A1 14/4885 |
| US-20230346782-A1 | COMPOSITIONS AND METHODS FOR TREATING GALACTOSEMIA | GLA, ALDOA, GALC | AKR1B1 42/4885AKR1B10 159/4885AKR1A1 74/4885 |
| US-20150072989-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | AKR1B1 2/4885AKR1B10 8/4885AKR1A1 5/4885 |
| US-20130225592-A1 | ALDOSE REDUCTASE INHIBITORS AND USES THEREOF | ALDOA, AKR1B1, AKR1C2 | AKR1B1 2/4885AKR1B10 8/4885AKR1A1 5/4885 |
| US-20230058134-A1 | ALDOSE REDUCTASE INHIBITORS FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME, ACUTE LUNG INFLAMMATION/INJURY, CARDIAC INJURY AND ANTI-VIRAL THERAPY | ALDOA, AKR1B1, ACE | AKR1B1 2/4885AKR1B10 17/4885AKR1A1 5/4885 |
| US-11730737-B2 | Aldose reductase inhibitors and uses thereof | ALDOA, AKR1B1, AKR1C2 | AKR1B1 2/4885AKR1B10 8/4885AKR1A1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.