Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | BMP4 | P12644 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362985 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1HPGDBMP4TP53 | |
| SCHEMBL9138422 | 0.76 | NCF1 (0.43) | KDM4EALDH1A1HPGDBMP4CASP1 | |
| SCHEMBL11316779 | 0.70 | FGFR1 (0.46) | KDM4EALDH1A1MEN1MAPTTSHR | |
| SCHEMBL4817117 | 0.68 | KDM4E (0.39) | LRRK2KDM4EMAP2K1RAF1ALDH1A1 | |
| SCHEMBL11315509 | 0.67 | KMT2A (0.49) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL15452583 | 0.66 | MKNK1 (0.46) | LRRK2KDM4EMAP2K1RAF1MEN1 | |
| SCHEMBL828123 | 0.65 | NCF1 (0.50) | LRRK2KDM4EMAP2K1RAF1ALDH1A1 | |
| SCHEMBL29619912 | 0.65 | NCF1 (0.50) | LRRK2KDM4EMAP2K1RAF1ALDH1A1 | |
| SCHEMBL1164857 | 0.65 | LRRK2 (0.54) | LRRK2KDM4EMAP2K1RAF1ALDH1A1 | |
| SCHEMBL1346465 | 0.65 | LRRK2 (0.54) | LRRK2KDM4EMAP2K1RAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |