Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | BMP4 | P12644 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | USP5 | P45974 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138422 | 0.79 | NCF1 (0.43) | KDM4ESMN1; SMN2GRM4BMP4NPC1 | |
| SCHEMBL362609 | 0.76 | LRRK2 (0.41) | KDM4EBMP4NPC1RAB9ATP53 | |
| SCHEMBL11315509 | 0.73 | KMT2A (0.49) | KDM4ESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL11316779 | 0.73 | FGFR1 (0.46) | KDM4ESMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL11318548 | 0.70 | SMN1; SMN2 (0.43) | KDM4ESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL5528658 | 0.68 | KDM4E (0.42) | KDM4EGPR3HSD17B10IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL9145064 | 0.67 | HCAR1 (0.46) | KDM4ESMN1; SMN2KMT2AMAPK1ALDH1A1 | |
| SCHEMBL29974345 | 0.67 | KDM4E (0.54) | KDM4EBMP4NPC1RAB9AGPR3 | |
| SCHEMBL361719 | 0.67 | KDM4E (0.54) | KDM4EBMP4NPC1RAB9AGPR3 | |
| SCHEMBL29648618 | 0.66 | KDM4E (0.49) | KDM4ESMN1; SMN2BMP4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |