Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618878 | 0.89 | PDE4A (0.43) | GSK3BMAP4K4SIRT6MKNK1MKNK2 | |
| SCHEMBL4768283 | 0.85 | KMT2A (0.57) | GSK3BMAP4K4SIRT6MKNK1MKNK2 | |
| SCHEMBL3347682 | 0.79 | KMT2A (0.49) | GSK3BMAP4K4MKNK1MKNK2PDE4A | |
| SCHEMBL4501855 | 0.79 | MARS1 (0.52) | MAP4K4PRF1 | |
| SCHEMBL447835 | 0.77 | MAOB (0.56) | MAP4K4SIRT6KMT2ALMNA | |
| SCHEMBL945743 | 0.77 | GSK3B (0.63) | GSK3BMAP4K4MKNK1MKNK2PDE4A | |
| SCHEMBL2927582 | 0.77 | HIF1A (0.53) | GSK3BMKNK1MKNK2PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL27870983 | 0.76 | MAOB (0.54) | MAP4K4SIRT6KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL3493985 | 0.76 | MAOB (0.54) | MAP4K4SIRT6KMT2ALMNA | |
| SCHEMBL27961477 | 0.75 | KMT2A (0.51) | GSK3BMAP4K4MKNK1MKNK2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | claimed |
| WO-2010108052-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2010-09-23 | — | — | WO | claimed |
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | disclosed |
| WO-2010108052-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2010-09-23 | — | — | WO | disclosed |