Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 12/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629813 | 0.78 | MBOAT4 (0.39) | MBOAT4MEN1NPC1CASP3KMT2A | |
| SCHEMBL3626810 | 0.77 | MBOAT4 (0.40) | MBOAT4KDM4EENPP1MEN1NPC1 | |
| SCHEMBL10372114 | 0.76 | NPC1 (0.56) | MBOAT4KDM4EENPP1MEN1NPC1 | |
| SCHEMBL14491199 | 0.71 | ALDH1A1 (0.49) | MBOAT4ENPP1 | |
| SCHEMBL373769 | 0.71 | MAP3K14 (0.48) | MBOAT4KDM4EMEN1KMT2A | |
| SCHEMBL3629809 | 0.69 | MBOAT4 (0.45) | MBOAT4KDM4E | |
| SCHEMBL302642 | 0.67 | MBOAT4 (0.50) | MBOAT4MEN1NPC1CASP3KMT2A | |
| SCHEMBL14373948 | 0.67 | USP2 (0.48) | MBOAT4KDM4EENPP1MEN1NPC1 | |
| SCHEMBL14490818 | 0.66 | KDM4E (0.56) | MBOAT4KDM4EENPP1MEN1NPC1 | |
| SCHEMBL14491955 | 0.66 | MBOAT4 (0.48) | MBOAT4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | claimed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | claimed |
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |