Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626353 | 0.95 | MAPT (0.44) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL3616710 | 0.93 | POLB (0.42) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL3620278 | 0.90 | RAB9A (0.50) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL14952822 | 0.90 | POLB (0.40) | RAB9AMEN1KMT2ANPC1ALKBH1 | |
| SCHEMBL4000881 | 0.88 | KEAP1 (0.50) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL14952869 | 0.86 | MEN1 (0.47) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL3625402 | 0.86 | MEN1 (0.41) | RAB9AMEN1KMT2ANPC1PTGER1 | |
| SCHEMBL3626358 | 0.85 | MAPT (0.44) | RAB9AMEN1KMT2ANPC1POLB | |
| SCHEMBL3627409 | 0.83 | POLB (0.39) | RAB9AMEN1KMT2ANPC1ALKBH1 | |
| SCHEMBL3995334 | 0.82 | KEAP1 (0.55) | RAB9AMEN1KMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |