Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14952822 | 0.94 | POLB (0.40) | POLBMAPTSMN1; SMN2ALKBH1KDM5A | |
| SCHEMBL3624474 | 0.90 | PTGER1 (0.38) | ALKBH1KDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL3998373 | 0.89 | KEAP1 (0.47) | POLBMAPTSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL3625402 | 0.87 | MEN1 (0.41) | ALKBH1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL3626353 | 0.86 | MAPT (0.44) | POLBMAPTSMN1; SMN2ALKBH1RAB9A | |
| SCHEMBL3620278 | 0.85 | RAB9A (0.50) | POLBMAPTSMN1; SMN2ALKBH1KDM5A | |
| SCHEMBL3616710 | 0.84 | POLB (0.42) | POLBMAPTSMN1; SMN2ALKBH1KDM5A | |
| SCHEMBL3627313 | 0.83 | RAB9A (0.47) | POLBMAPTSMN1; SMN2ALKBH1RAB9A | |
| SCHEMBL3628869 | 0.83 | KDM4C (0.39) | POLBMAPTSMN1; SMN2KDM5AKDM4C | |
| SCHEMBL3998252 | 0.82 | KEAP1 (0.48) | POLBMAPTSMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |