Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | MTOR | P42345 | 4/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.34 |
| ▸ | FEN1 | P39748 | 3/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3090583 | 0.81 | PIK3CA (0.46) | SMOPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL3634324 | 0.79 | PIK3CA (0.43) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3627322 | 0.78 | F10 (0.39) | PIK3CACYP11B2PIK3CBMTORPIK3CG | |
| SCHEMBL3080404 | 0.76 | SMO (0.49) | SMOPIK3CATLR9TLR8TLR7 | |
| SCHEMBL3635713 | 0.76 | HCRTR1 (0.51) | PIK3CA | |
| SCHEMBL3629011 | 0.74 | GBA1 (0.44) | PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3629695 | 0.73 | MAPT (0.44) | PIK3CACYP11B2PIK3CBPIK3CGPIK3CD | |
| SCHEMBL3633555 | 0.73 | SLC6A7 (0.44) | — | |
| SCHEMBL3630355 | 0.73 | PIK3CB (0.39) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL3087863 | 0.69 | PIK3CB (0.46) | PIK3CACYP11B2PIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |