Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3627842 | 0.96 | HTR2A (0.35) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL29843993 | 0.96 | HTR2A (0.38) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL60904 | 0.96 | HTR2A (0.38) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL9143696 | 0.94 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL9141944 | 0.94 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Lithium SCHEMBL9141948 | 0.94 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL9143717 | 0.94 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL6771310 | 0.92 | HTR2A (0.35) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL6772747 | 0.92 | HTR2A (0.35) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL1028330 | 0.85 | HTR2A (0.39) | HTR2AHTR6SIGMAR1KDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082355-B1 | CATALYST COMPOSITION FOR POLYMERIZING MONOMERS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2008-10-15 | — | — | EP | claimed |
| US-20050197470-A1 | Compositions that can produce polymers | PHILLIPS PETROLEUM COMPANY | 2005-09-08 | — | — | US | claimed |
| US-6831141-B2 | Contacting organometal compound, treated solid oxide compound, organoaluminum compound to produce metallocene catalysts | PHILLIPS PETROLEUM COMPANY | 2004-12-14 | — | — | US | claimed |
| US-20040143078-A1 | Compositions that can produce polymers | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2004-07-22 | — | — | US | claimed |
| US-20030120002-A1 | Polymerization process utilizing an organometal compound, organoaluminum compound and a solid mixed oxide compound | PHILLIPS PETROLEUM COMPANY | 2003-06-26 | — | — | US | claimed |
| US-6531550-B1 | Process for producing polymers | PHILLIPS PETROLEUM COMPANY | 2003-03-11 | — | — | US | claimed |
| US-20020007023-A1 | Process for producing polymers | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2002-01-17 | — | — | US | claimed |
| EP-1082355-A1 | CATALYST COMPOSITION FOR POLYMERIZING MONOMERS | Phillips Petroleum Company (US) | 2001-03-14 | — | — | EP | claimed |
| US-6107230-A | COMPRISING CONTACTING AT LEAST ONE ORGANOMETAL COMPOUND AND AT LEAST ONE ORGANOALUMINUM COMPOUND WITH AT LEAST ONE TREATED SOLID OXIDE COMPOUND | PHILLIPS PETROLEUM COMPANY (US) | 2000-08-22 | — | — | US | claimed |
| WO-1999060033-A1 | CATALYST COMPOSITION FOR POLYMERIZING MONOMERS | PHILLIPS PETROLEUM COMPANY (US) | 1999-11-25 | — | — | WO | claimed |
| EP-2261266-B1 | PROCESS FOR THE POLYMERIZATION OF A MONOMER WITH A CATALYST COMPOSITION CONTAINING AN ORGANOMETAL COMPOUND, AN ORGANOALUMINUM COMPOUND AND A TREATED SOLID OXIDE COMPOUND | CHEVRON PHILLIPS CHEMICAL CO (US) | 2016-03-23 | — | — | EP | disclosed |
| EP-1995258-B1 | Catalyst composition for polymerizing monomers | CHEVRON PHILLIPS CHEMICAL CO (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2261266-A2 | Process for the polymerization of a monomer with a catalyst composition containing an organometal compound, an organoaluminum compound and a treated solid oxide compound | Chevron Phillips Chemical Company LP (US) | 2010-12-15 | — | — | EP | disclosed |
| US-7601665-B2 | Compositions that can produce polymers | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2009-10-13 | — | — | US | disclosed |
| EP-1995258-A2 | Catalyst composition for polymerizing monomers | Chevron Phillips Chemical Company LP (US) | 2008-11-26 | — | — | EP | disclosed |
| US-6531550-B1 | Process for producing polymers | PHILLIPS PETROLEUM COMPANY | 2003-03-11 | — | — | US | disclosed |
| US-20020007023-A1 | Process for producing polymers | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2002-01-17 | — | — | US | disclosed |
| EP-1082355-A1 | CATALYST COMPOSITION FOR POLYMERIZING MONOMERS | Phillips Petroleum Company (US) | 2001-03-14 | — | — | EP | disclosed |
| US-6107230-A | COMPRISING CONTACTING AT LEAST ONE ORGANOMETAL COMPOUND AND AT LEAST ONE ORGANOALUMINUM COMPOUND WITH AT LEAST ONE TREATED SOLID OXIDE COMPOUND | PHILLIPS PETROLEUM COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999060033-A1 | CATALYST COMPOSITION FOR POLYMERIZING MONOMERS | PHILLIPS PETROLEUM COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |