Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.41 |
| ▸ | GPR6 | P46095 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424533 | 0.85 | ROCK2 (0.43) | ROCK2PRKCZPRKD2GPR6DYRK1A | |
| SCHEMBL2425647 | 0.85 | ROCK2 (0.43) | ROCK2PRKCZPRKD2GPR6DYRK1A | |
| SCHEMBL2425868 | 0.85 | ROCK2 (0.45) | ROCK2PRKCZPRKD2GPR6ROCK1 | |
| SCHEMBL13087712 | 0.85 | ROCK2 (0.45) | ROCK2PRKCZPRKD2GPR6ROCK1 | |
| SCHEMBL2494550 | 0.85 | GPR119 (0.48) | ROCK2DYRK1AIRAK4 | |
| SCHEMBL2422864 | 0.84 | CYP1A2 (0.52) | ROCK2PRKCZPRKD2CYP1A2CYP2C19 | |
| SCHEMBL13087242 | 0.84 | ROCK2 (0.41) | ROCK2PRKCZPRKD2GPR6SLC22A12 | |
| SCHEMBL13087319 | 0.84 | ROCK2 (0.41) | ROCK2PRKCZPRKD2GPR6IRAK4 | |
| SCHEMBL15172446 | 0.84 | ROCK2 (0.48) | ROCK2PRKCZPRKD2GPR6ROCK1 | |
| SCHEMBL2425114 | 0.84 | CYP1A2 (0.44) | ROCK2PRKCZPRKD2GPR6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038465-A1 | 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF | 旭化成ファーマ株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |